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Chemicals
C-Type Natriuretic Peptide (1-53) (human) CAS NO.141294-77-1
<p>C-Type Natriuretic Peptide (1-53) (human) (CAS NO. 141294-77-1) is a synthetic, full-length 53-amino acid peptide representing the complete, biologically active form of human CNP. This high-purity, research-grade peptide is a crucial endogenous ligand for the natriuretic peptide receptor B (NPR-B/GC-B) and serves as a fundamental tool for studying cardiovascular development, endochondral bone growth, and vascular…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | C-Type Natriuretic Peptide (1-53) (human) |
| CAS NO. | 141294-77-1 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C251H417N81O71S3 |
| Molecular Weight | 5801.81g/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in water (≥1 mg/mL), dilute acetic acid, or 0.1% TFA in water; sparingly soluble in methanol |
| Endotoxin | ≤1.0 EU /mg |
| Biological Activity | Potent vasorelaxant activity; EC₅₀ typically in the range of 0.1–1.0 nM in isolated vascular tissue assays. |
| Storage Conditions | Store at ≤ -20°C in a dry, dark environment. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
This peptide specifically binds to and activates the natriuretic peptide receptor B (NPR-B), which possesses intrinsic guanylyl cyclase activity. The binding leads to a significant increase in intracellular cyclic guanosine monophosphate (cGMP) production in target cells.
2.PRODUCT INDICATIONS
This product is indicated for in vitro and in vivo research in endocrinology, skeletal biology, and cardiovascular science. Key applications include: studying the regulation of endochondral ossification and bone growth disorders, investigating CNP's role in cardiovascular homeostasis and vascular remodeling, serving as the definitive reference agonist in NPR-B receptor binding and functional (cGMP) assays, and exploring potential therapeutic applications for skeletal dysplasias (e.g., achondroplasia) and pulmonary hypertension.
3.CLINICAL EFFICACY OF PRODUCT
Human CNP(1-53) is a research peptide and not an approved drug. However, its profound biological role as the primary activator of the NPR-B/cGMP pathway in growth plates makes it a direct therapeutic prototype. Research using this peptide has validated CNP supplementation as a treatment strategy for growth disorders.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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Global Technology Co., Ltd.
