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Chemicals
γ-MSH (3-8) CAS NO.98640-70-1
<p>γ-MSH (3-8) (CAS NO. 98640-70-1) is a synthetic hexapeptide fragment corresponding to residues 3-8 of the gamma-Melanocyte-Stimulating Hormone (γ-MSH). This short, stable, and high-purity sequence retains core structural motifs that confer specific binding activity. It is an essential research-grade tool for investigating the structure-activity relationships and selective signaling functions of γ-MSH-derived pept…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | γ-MSH (3-8) |
| CAS NO. | / |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C39H52N12O7S |
| Molecular Weight | 832.98 g/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in water (≥20 mg/mL), dilute acetic acid, or 5% DMSO in aqueous buffer |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Agonist of melanocortin receptors (MC1R, MC3R, MC5R); modulates pigmentation, anti-inflammatory responses and energy metabolism |
| Storage Conditions | Store at -20°C to -80°C in a dry, dark environment; avoid repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
This short peptide fragment functions as a ligand for melanocortin receptors (MCRs). While its shorter length typically reduces overall receptor affinity compared to full-length γ-MSH, the γ-MSH (3-8) core sequence is critical for receptor interaction and can retain partial agonist or antagonist activity depending on the receptor subtype (primarily MC3R).
2.PRODUCT INDICATIONS
This product is indicated for fundamental research in neuroendocrinology, pharmacology, and peptide chemistry. Key applications include: studying the minimal active sequence and structure-activity relationship (SAR) of γ-MSH, investigating selective binding and functional profiles at melanocortin receptor subtypes (MC3R/MC4R), developing radiolabeled ligands or fluorescent probes for receptor binding assays, and serving as a reference standard in the synthesis and screening of novel melanocortin peptide analogs.
3.CLINICAL EFFICACY OF PRODUCT
γ-MSH (3-8) is a basic research tool and not a therapeutic agent. Its efficacy is defined by its role in elucidating the core pharmacophore of γ-MSH. Research using this and similar fragments has been crucial for mapping the critical binding regions of melanocortin peptides. This foundational knowledge aids in the rational, fragment-based design of highly selective, stable, and potent melanocortin receptor agonists or antagonists with potential future clinical applications in metabolic disorders, inflammation, or cardiovascular diseases.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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Global Technology Co., Ltd.
