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Chemicals
[Des-Asp187]-Melanocyte Protein PMEL 17 (185-193) (human, bovine, mouse) CAS NO.319927-23-6
<p>[Des-Asp187]-Melanocyte Protein PMEL 17 (185-193) (human, bovine, mouse) (CAS NO. 319927-23-6) is a synthetic, nonameric peptide corresponding to a conserved epitope of the PMEL17/gp100 protein with a specific deletion of aspartic acid at position 187. This modified, high-purity peptide is a critical research tool in immunology and oncology, specifically designed to study T-cell responses against melanoma and oth…
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About this product
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | [Des-Asp¹⁸⁷]-Melanocyte Protein PMEL 17 (185-193) (human, bovine, mouse) |
| CAS NO. | 319927-23-6 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C42H67N9O12 |
| Molecular Weight | 890.06g/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in water (≥5 mg/mL), dilute acetic acid, or 5% DMSO in water |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Melanoma-associated antigen peptide; used to induce antigen-specific T-cell responses, for cancer immunology research and vaccine development |
| Storage Conditions | Store at -20°C to -80°C in a dry, dark environment; avoid repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
This peptide functions as an altered peptide ligand (APL) derived from the melanocyte differentiation antigen PMEL17/gp100. The deletion of Asp187 ([Des-Asp187]) modifies its structural and charge properties, potentially altering its processing by antigen-presenting cells and its subsequent presentation by HLA class I molecules (commonly HLA-A*0201). This modification can lead to differential activation of cytotoxic T lymphocytes (CTLs), allowing for the study of T-cell receptor (TCR) affinity, cross-reactivity, and the induction of specific immune responses against tumor cells expressing the wild-type gp100 antigen.
2.PRODUCT INDICATIONS
This product is indicated for immunological and cancer research. Key applications include: investigating T-cell recognition and cross-reactivity in melanoma immunotherapy, studying altered peptide ligand (APL) strategies to enhance or modulate anti-tumor immunity, evaluating the efficacy of adoptive T-cell therapies and peptide vaccines in preclinical models, and serving as a key antigen in immunological assays such as ELISpot, MHC multimer staining, and T-cell stimulation assays.
3.CLINICAL EFFICACY OF PRODUCT
This product is indicated for immunological and cancer research. Key applications include: investigating T-cell recognition and cross-reactivity in melanoma immunotherapy, studying altered peptide ligand (APL) strategies to enhance or modulate anti-tumor immunity, evaluating the efficacy of adoptive T-cell therapies and peptide vaccines in preclinical models, and serving as a key antigen in immunological assays such as ELISpot, MHC multimer staining, and T-cell stimulation assays.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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