[D-Leu2]-Melanocyte-Stimulating Hormone-Release Inhibiting Factor CAS NO.39705-60-7

<p>[D-Leu2]-Melanocyte-Stimulating Hormone-Release Inhibiting Factor is a synthetic peptide analog of the endogenous melanocyte-stimulating hormone release inhibiting factor (MIF), featuring a D-leucine substitution at position 2 to enhance metabolic stability and biological activity. This research-grade reagent is designed as a potent inhibitor of melanocyte-stimulating hormone (MSH) release and activity, with appl…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[D-Leu2]-Melanocyte-Stimulating Hormone-Release Inhibiting Factor
CAS NO.	39705-60-7
Appearance	White to off-white lyophilized powder
Molecular Formula	C13H24N4O3
Molecular Weight	284.36g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	It is soluble in water, physiological saline or dilute acetic acid solution.
Endotoxin	< 1.0 EU/mg
Biological Activity	This product is an analogue of melanocyte-stimulating hormone-releasing inhibitory factor (MIF). D-Leu2 modification enhances enzyme stability and bioavailability, and it can inhibit the release or activity of α-MSH. Its bioactivity needs to be verified through in vitro melanocyte inhibition experiments or related receptor function experiments.
Storage Conditions	Freeze-dried powder should be stored at -20°C or lower in a dry, light-protected environment; reconstituted solutions should be aliquoted and stored at ≤-20°C, avoiding repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The mechanism of action involves inhibition of melanocyte-stimulating hormone (MSH) release and/or antagonism of MSH activity at its receptors. The peptide likely acts through interaction with specific receptors or regulatory pathways in the hypothalamus or pituitary that control MSH secretion, potentially modulating the release of α-MSH and other melanocortins. The D-leucine substitution at position 2 enhances resistance to enzymatic degradation, prolonging the peptide's half-life and increasing its inhibitory potency compared to the native MIF sequence. This enhanced stability allows for more sustained suppression of MSH-mediated effects, making it a more effective research tool for studying the regulation of melanogenesis and related physiological processes.

2.PRODUCT INDICATIONS

This MIF analog is indicated for research use only in preclinical studies investigating the regulation of melanocyte-stimulating hormone release, melanogenesis mechanisms, skin pigmentation disorders, and neuroendocrine control of pigmentation. It serves as a potent inhibitor in studies examining MSH secretion, melanin synthesis assays, and animal models of hyperpigmentation or pigmentary disorders. The product is also used in structure-activity relationship studies to understand peptide-receptor interactions and in the development of compounds targeting MSH regulation. It is not intended for diagnostic, therapeutic, or clinical applications in humans or animals, and should be handled by trained research personnel in appropriate laboratory settings.

3.CLINICAL EFFICACY OF PRODUCT

As a research reagent, [D-Leu2]-Melanocyte-Stimulating Hormone-Release Inhibiting Factor does not have established clinical efficacy for therapeutic use in human patients. While this peptide analog and related compounds have been studied in preclinical models to understand MSH regulation and potential applications in pigmentary disorders, the product itself has not undergone clinical development or received regulatory approval for any medical indication. Research using this peptide has contributed to the understanding of melanocortin regulatory pathways, but the product remains an investigational research tool without proven clinical efficacy or safety profile for human use.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
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