Biotin-MBP Derivatized Peptide

Biotin-MBP Derivatized Peptide  is a high-purity biotinylated research peptide with a representative molecular formula of C105H166N28O25  and a molecular weight of 2252.73g/mol  (varies by specific MBP sequence). This lyophilized white to …

SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Biotin-MBP Derivatized Peptide
CAS NO.	\
Appearance	White to off-white lyophilized powder
Molecular Formula	C105H166N28O25
Molecular Weight	2252.73g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, 1% acetic acid, or DMSO
Endotoxin	< 1.0 EU/mg
Biological Activity	A biotinylated analog of myelin basic protein (MBP) fragments, designed for detection and purification in immunology research. It retains MHC class II binding and T-cell activation properties, while the biotin tag enables conjugation to streptavidin-coated surfaces for assays like ELISAs, pull-downs, and flow cytometry.
Storage Conditions	Store at -20°C in a desiccated environment. Avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The MBP fragment core of Biotin-MBP Derivatized Peptide binds to MHC class II molecules (e.g., I-Aᵘ, I-Eᵏ) with high affinity, mimicking native MBP epitopes to activate autoreactive CD4⁺ T cells—replicating the key immunological cascade in MS and EAE.

The covalently attached biotin tag does not interfere with the peptide’s biological activity; instead, it enables specific conjugation to streptavidin-coated surfaces, beads, or detection reagents (e.g., streptavidin-HRP, streptavidin-fluorophores).

This dual functionality allows researchers to both study the peptide’s immunological effects and track its interactions with target molecules (e.g., MHC proteins, T-cell receptors) via high-sensitivity assays

2.PRODUCT INDICATIONS

Research Use Only (RUO): For in vitro and in vivo studies of MS pathogenesis, EAE models, MHC-peptide-TCR interactions, and T-cell activation.

Ideal for assays requiring specific detection or purification, including ELISAs, pull-down assays, flow cytometry, immunoprecipitation, and peptide microarray immobilization.

Suitable for validating MBP-specific antibodies, screening immunomodulatory therapies, and investigating the role of MBP epitopes in autoimmune neuroinflammation.

Customizable for targeted research: available for biotinylation of any MBP fragment to match specific epitope interests.

3.CLINICAL EFFICACY OF PRODUCT

Biotin-MBP Derivatized Peptide is a preclinical research reagent and has not undergone human clinical trials.

In preclinical EAE models, it maintains the ability to induce or modulate autoimmune responses, serving as a valuable tool for evaluating the efficacy of potential MS therapies (e.g., peptide vaccines, monoclonal antibodies).

Its streptavidin-biotin conjugation capability enhances assay sensitivity, enabling accurate quantification of MHC-peptide binding affinity and T-cell activation—supporting the development and validation of novel immunotherapies.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.