MBP (90-106)

<div class="ybc-p">MBP (90-106) is a synthetic peptide fragment corresponding to amino acid residues 90-106 of human myelin basic protein, a key component of the myelin sheath in the central nervous system. This research-grade peptide serves as an important immunodominant epitope in autoimmune and neurological studies, particularly for investigating T-cell mediated immune responses. The product is synthesized to hig…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	MBP (90-106)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C91H143N25O23
Molecular Weight	1955.31g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	It is recommended to first dissolve the sample in a small amount of dilute acetic acid solution (<1% v="">
Endotoxin	< 1.0 EU/mg
Biological Activity	This product contains a key immunodominant segment of MBP, which can induce an immune response in an experimental autoimmune encephalomyelitis (EAE) animal model and stimulate the proliferation of antigen-specific T cells or cytokine secretion in vitro. Specific bioactivity should be referenced from batch-specific in vitro T cell stimulation experimental data.
Storage Conditions	Store at -20°C or lower in a dry environment away from light; it is stable over a long period. For reconstituted solutions: it is recommended to aliquot and store frozen at ≤-20°C, avoiding repeated freeze-thaw cycles. Under proper storage conditions, the shelf life of lyophilized powder can typically reach several years.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The mechanism of action of MBP (90-106) involves its recognition by T-cell receptors (TCRs) when presented by major histocompatibility complex (MHC) class II molecules on antigen-presenting cells. This peptide-MHC complex engagement triggers T-cell activation, proliferation, and cytokine production, which can lead to the initiation or modulation of immune responses. In experimental settings, this peptide has been shown to induce encephalitogenic responses in susceptible animal models, making it a valuable tool for studying the pathogenesis of autoimmune diseases like multiple sclerosis. The specific amino acid sequence within this region contains critical residues that determine its immunogenicity and binding affinity to MHC molecules, influencing the nature and intensity of the resulting immune response.

2.PRODUCT INDICATIONS

MBP (90-106) is indicated for research use only in the fields of immunology, neuroscience, and autoimmune disease research. It is specifically employed as an antigenic stimulus in studies investigating T-cell responses, epitope mapping, and the development of experimental autoimmune encephalomyelitis (EAE) models. The product serves as a standard reagent for characterizing autoantibody responses, validating diagnostic assays, and exploring immune tolerance mechanisms. It is also used in cell-based assays to study antigen presentation and T-cell activation pathways. This peptide is not intended for diagnostic, therapeutic, or clinical applications in humans or animals, and should be handled by trained personnel in appropriate laboratory settings.

3.CLINICAL EFFICACY OF PRODUCT

As a research reagent, MBP (90-106) does not have established clinical efficacy for therapeutic use in human patients. Its utility is confined to preclinical research applications, where it has been extensively used to study the immunopathogenesis of multiple sclerosis and other demyelinating diseases in animal models. While research using this peptide has contributed significantly to our understanding of autoimmune mechanisms and has facilitated the development of experimental therapeutic approaches, the product itself has not been evaluated in clinical trials for safety or efficacy. Any potential clinical applications derived from research findings would require separate development of diagnostic or therapeutic products that undergo rigorous clinical testing and regulatory approval processes.

4.DELIVERY & SHIPPING

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Main Method: International Air Freight

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