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Chemicals
MBP (74 – 85), guinea pig
<p>MBP (74-85), guinea pig is a synthetic peptide fragment corresponding to amino acid residues 74-85 of the guinea pig Myelin Basic Protein (MBP). This high-purity, defined antigen is a cornerstone research tool in neuroimmunology, specifically recognized as a primary encephalitogenic epitope for inducing the classical Experimental Autoimmune Encephalomyelitis (EAE) model, which is fundamental for studying the immu…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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About this product
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Myelin Basic Protein (74-85), guinea pig |
| CAS NO. | / |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C56H94N20O23 |
| Molecular Weight | 1415.49 g/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in water, dilute acetic acid, and neutral buffers |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | A major encephalitogenic epitope of guinea pig myelin basic protein, capable of inducing experimental autoimmune encephalomyelitis (EAE) in guinea pigs and other susceptible rodents |
| Storage Conditions | Store at -20°C in a dry, sealed container; avoid repeated freeze-thaw cycles and exposure to moisture. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
This peptide acts as a dominant antigenic determinant. When administered with an adjuvant to susceptible guinea pigs, it is processed by antigen-presenting cells and presented in the context of Major Histocompatibility Complex (MHC) Class II molecules. This presentation potently activates autoreactive CD4+ T helper cells, triggering a cascade of pro-inflammatory cytokine release and cellular infiltration into the central nervous system.
2.PRODUCT INDICATIONS
This product is indicated for preclinical research in autoimmune and neurological disorders. Its primary application is the reliable induction of EAE in guinea pigs for: investigating the mechanisms of autoimmune demyelination, evaluating the efficacy and mode of action of potential therapeutic agents for multiple sclerosis, and studying fundamental processes of T-cell activation, epitope spreading, and immune tolerance in a controlled in vivo setting.
3.CLINICAL EFFICACY OF PRODUCT
As a research reagent, MBP (74-85), guinea pig is not used in clinical treatment. Its efficacy is defined by its robust and reproducible capacity to induce EAE, making it a gold-standard tool for over half a century. This model has been instrumental in validating the autoimmune basis of MS and has served as the primary preclinical screening platform for the vast majority of immunomodulatory and immunosuppressive therapies currently approved for MS, directly linking its research use to clinical advancement.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
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Global Technology Co., Ltd.
