[Arg91, Ala96] – MBP (87 – 99), human

<p><br/></p><div class="ybc-p">[Arg91, Ala96] - MBP (87-99), human is a high-purity synthetic peptide analog of the human myelin basic protein (MBP) encephalitogenic epitope, featuring specific amino acid substitutions at positions 91 (Ile→Arg) and 96 (Thr→Ala). This modified 13-amino acid peptide (VHFFKNRVAPRTP) is engineered to study structure-activity relationships in autoimmune epitope recognition, T cell activa…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Arg91, Ala96] - MBP (87 - 99), human
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C72H112N22O17
Molecular Weight	1557.83g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, PBS (pH 7-8), or an aqueous solution containing a small amount of DMSO.
Endotoxin	< 1.0 EU/mg
Biological Activity	Modified MBP autoimmune epitopes; Ile→Arg at position 91, Thr→Ala at position 96, may alter its immunogenicity, MHC binding, or T cell recognition properties, and can be used for multiple sclerosis models, autoimmune epitope optimization, and T cell research.
Storage Conditions	Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

[Arg91, Ala96] - MBP (87-99) functions as a modified autoantigen that interacts with MHC class II molecules on antigen-presenting cells, forming peptide-MHC complexes recognized by CD4⁺ T cell receptors. The Arg91 and Ala96 substitutions alter the peptide's binding affinity for MHC molecules and its interaction with T cell receptors, potentially modulating the activation threshold of autoreactive T cells. This modified epitope can induce differential T cell responses compared to the wild-type sequence, leading to altered cytokine profiles (Th1/Th2/Th17 polarization) and modified encephalitogenic potential. The peptide serves as a valuable tool for studying how specific amino acid changes in autoantigens influence immune recognition, T cell activation kinetics, and the development of autoimmune pathology in neuroinflammatory models.

2.PRODUCT INDICATIONS

Autoimmune Disease Research: Investigation of multiple sclerosis mechanisms and neuroinflammatory disorders using modified autoantigens

Epitope Optimization Studies: Analysis of how specific amino acid substitutions affect autoimmune epitope recognition and immunogenicity

T Cell Receptor Research: Study of TCR recognition specificity and activation thresholds using modified MBP epitopes

EAE Model Development: Induction and modulation of experimental autoimmune encephalomyelitis with engineered autoantigens

Immunotherapy Development: Screening and evaluation of antigen-specific tolerogenic or immunomodulatory strategies

Structure-Activity Relationship: Investigation of peptide-MHC and peptide-TCR interactions through systematic epitope modification

3.CLINICAL EFFICACY OF PRODUCT

Structural Precision: Verified VHFFKNRVAPRTP sequence with specified modifications

Biological Relevance: Validated in MHC binding assays, T cell activation studies, and EAE models

Research Utility: Enables precise investigation of epitope-immune system interactions with controlled modifications

4.DELIVERY & SHIPPING

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Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight

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