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Chemicals
MART-1 (26-35) (human) CAS NO.156251-01-3
<p>MART-1 (26-35) (human) is a synthetic decapeptide corresponding to residues 26-35 of the human melanoma antigen recognized by T-cells (MART-1). With CAS NO. 156251-01-3, it is a high-purity, well-defined research tool primarily used in immunology and oncology to study T-cell mediated immune responses against melanoma and other cancers.</p>
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | MART-1 (26-35) (human) |
| CAS NO. | 156251-01-3 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C42H74N10O14 |
| Molecular Weight | 943.12g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, 0.1 M acetic acid, or DMSO at a concentration ≥ 1 mg/mL. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Recognized by HLA-A2-restricted cytotoxic T lymphocytes (CTLs) specific to MART-1. |
| Storage Conditions | Store long-term at -20°C to -80°C; avoid repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
This peptide is a native HLA-A*02:01-restricted epitope derived from the melanocyte differentiation antigen MART-1/Melan-A. When presented by antigen-presenting cells (APCs), it effectively activates antigen-specific cytotoxic T-lymphocytes (CTLs). These activated CTLs then recognize and eliminate tumor cells expressing the endogenous MART-1 protein, providing a specific target for adaptive anticancer immunity.
2.PRODUCT INDICATIONS
This peptide is indicated for use in scientific research applications, including: in vitro T-cell stimulation and expansion, immune monitoring assays, development and evaluation of peptide-based cancer vaccines, assessment of adoptive T-cell therapy efficacy, and as a critical reagent for studying antigen-specific immune responses in melanoma and vitiligo research.
3.CLINICAL EFFICACY OF PRODUCT
As a research-grade reagent, MART-1 (26-35) is a cornerstone antigen in numerous clinical investigations. Studies have demonstrated its ability to consistently induce robust MART-1-specific T-cell responses in vitro and in vivo. It has been widely used in clinical trials for melanoma vaccines and adoptive T-cell transfer therapies, showing safety and immunogenicity, though therapeutic efficacy can vary based on the treatment modality and patient factors.
4.DELIVERY & SHIPPING
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Global Technology Co., Ltd.
