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Chemicals
MAGE-3 Antigen (271-279), human CAS NO.160295-81-8
<p>MAGE-3 Antigen (271-279), human is a synthetic peptide corresponding to residues 271–279 of the human melanoma-associated antigen MAGE-3. This high-purity antigen is designed for research and diagnostic applications, particularly in immunology and cancer studies. It serves as a critical tool for T-cell stimulation, epitope mapping, and the development of targeted cancer immunotherapies.</p>
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | MAGE-3 Antigen (271-279), human |
| CAS NO. | 160295-81-8 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C53H79N13O10 |
| Molecular Weight | 1058.3g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, 0.1 M acetic acid, or DMSO at a concentration of ≥ 1 mg/mL |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Recognized by HLA-A2-restricted cytotoxic T lymphocytes (CTLs) specific for MAGE-3 |
| Storage Conditions | Store at -20°C to -80°C for long-term storage; avoid repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The peptide acts as a human leukocyte antigen (HLA)-restricted epitope, primarily presented by HLA-A2 molecules on antigen-presenting cells. Upon presentation, it activates cytotoxic T-lymphocytes (CTLs) specific to MAGE-3-expressing tumors, triggering an immune response aimed at eliminating malignant cells. This mechanism underpins its utility in studying T-cell recognition and antitumor immunity.
2.PRODUCT INDICATIONS
This antigen is indicated for use in scientific research, including in vitro T-cell activation assays, immunotherapy development, and immunological studies targeting melanoma and other MAGE-3-positive cancers. It is also employed in diagnostic reagent development and vaccine research to evaluate immune responses against tumor-associated antigens.
3.CLINICAL EFFICACY OF PRODUCT
While primarily for research use, studies demonstrate that MAGE-3-derived peptides can induce specific CTL responses in preclinical models, supporting their potential in adoptive cell therapies and cancer vaccine platforms. Clinical trials involving MAGE-3 antigens have shown promise in eliciting antitumor immunity, highlighting its relevance in advancing personalized cancer treatments.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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Global Technology Co., Ltd.
