Luteinizing Hormone-Releasing Hormone, free acid, human; LH-RH, free acid, human

<p>Luteinizing Hormone-Releasing Hormone, free acid, human (LH-RH, free acid) is a high-purity synthetic decapeptide representing the native human gonadotropin-releasing hormone (GnRH) in its free acid form. This 10-amino acid neuropeptide plays a pivotal role in regulating the hypothalamic-pituitary-gonadal axis, controlling reproductive functions. Manufactured under stringent quality controls with HPLC-verified pu…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Luteinizing Hormone-Releasing Hormone, free acid, human; LH-RH, free acid, human
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C58H81N17O16S
Molecular Weight	1304.45g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, dilute acetic acid (0.1%), PBS (pH 7‑8)
Endotoxin	< 1.0 EU/mg
Biological Activity	Gonadotropin-releasing hormone (GnRH) in its free acidic form; it binds to pituitary GnRH receptors, influencing the synthesis and release of luteinizing hormone and follicle-stimulating hormone, and regulating the reproductive axis.
Storage Conditions	Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

LH-RH, free acid functions as a key neuroendocrine regulator by binding to specific G-protein coupled GnRH receptors in the anterior pituitary. This binding activates phospholipase C-mediated signaling pathways, leading to increased intracellular calcium levels and protein kinase C activation. The downstream effects stimulate the synthesis and release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which subsequently regulate gonadal steroidogenesis, gametogenesis, and reproductive behaviors. The free acid C-terminus may influence receptor binding affinity, metabolic stability, and clearance kinetics compared to amidated forms, providing insights into structure-activity relationships and peptide metabolism. This form is particularly useful for studying the impact of C-terminal modifications on receptor activation and downstream signaling cascades.

2.PRODUCT INDICATIONS

Reproductive Endocrinology Research: Study of hypothalamic-pituitary-gonadal axis regulation

GnRH Receptor Pharmacology: Investigation of receptor binding, activation, and signaling mechanisms

Structure-Activity Relationship Studies: Comparative analysis of free acid vs. amidated forms

Peptide Metabolism Research: Investigation of metabolic stability and clearance pathways

Drug Discovery: Screening for GnRH analogs and modulators

Comparative Endocrinology: Study of GnRH system across species and peptide variants

3.CLINICAL EFFICACY OF PRODUCT
Structural Authenticity: Verified free acid C-terminus (COOH) and native human sequence

Biological Relevance: Validated in receptor binding and functional assays

Research Reproducibility: Consistent performance in pharmacological and biochemical studies

Low Endotoxin:<1.0 eu="">

Technical Support: Access to application guidance for reproductive endocrinology research

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.