LHRH, salmon CAS NO.86073-88-3

<p>LHRH, salmon (also known as sGnRH or salmon Gonadotropin-Releasing Hormone) is a decapeptide neurohormone with the specific amino acid sequence: Trp⁷,Leu⁸-LHRH (pGlu-His-Trp-Ser-Tyr-Gly-Trp-Leu-Pro-Gly-NH₂). This variant differs from mammalian LHRH (GnRH) at positions 7 and 8, where Trp and Leu replace Leu and Arg. It is the native releasing hormone in salmonid fish and exhibits potent gonadotropin-releasing acti…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	LHRH, salmon
CAS NO.	86073-88-3
Appearance	White to off-white lyophilized powder
Molecular Formula	C60H73N15O13
Molecular Weight	1212.36g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, dilute PBS (pH 7.0-7.4), 0.1% TFA aqueous solution (typical solubility ≥5 mg/mL.
Endotoxin	< 1.0 EU/mg
Biological Activity	Endogenous salmon gonadotropin-releasing hormone; high-affinity binding to teleost fish gonadotrope LHRH receptors, potently stimulates LH and FSH secretion to regulate fish reproductive axis.
Storage Conditions	Store at -20°C to -80°C in a sealed, dry and light-protected container.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Salmon LHRH functions by binding and activating the specific GnRH receptors (GnRH-R) present in the pituitary gland of salmon and other teleost fish. Similar to its mammalian counterpart, it acts as a ligand for G-protein coupled receptors (GPCRs), primarily of the Gq/11 type. Upon binding to its cognate receptor on gonadotrope cells, it triggers a signaling cascade involving phospholipase C (PLC) activation, production of inositol trisphosphate (IP₃) and diacylglycerol (DAG), leading to intracellular calcium mobilization and protein kinase C (PKC) activation.

2.PRODUCT INDICATIONS

Aquaculture & Fisheries Management: Used to induce ovulation and spermiation in commercially important salmonid species (e.g., salmon, trout) and other teleosts for controlled breeding and hatchery operations.
Reproductive Physiology Studies: Investigating the neuroendocrine control of reproduction, puberty, and seasonal breeding cycles in fish models.
Comparative Endocrinology: Studying the evolution, structure-function relationships, and receptor specificity of GnRH variants across different vertebrate species.
In VivoInduction Experiments: Administering to fish via injection or implantation to study its effects on gonadal development, sex steroid hormone levels, and spawning behavior.

3.CLINICAL EFFICACY OF PRODUCT

Proven Efficacy in Aquaculture: It is widely used and regarded as highly effective for inducing final gamete maturation and spawning in various farmed fish species, particularly salmonids. Its use has revolutionized hatchery production by allowing for controlled, out-of-season, and synchronized breeding.
Standard Practice: The use of salmon LHRH or its analogs (e.g., D-Ala⁶, Pro⁹-NEt sGnRH, also known as Ovaprim™) is a standard spawning induction protocol in commercial aquaculture worldwide. It reliably leads to high rates of ovulation and spermiation.
Regulatory Status: It is a key active ingredient in approved veterinary products for fish breeding. Its efficacy and safety profiles for this purpose are well-documented through decades of practical application.

4.DELIVERY & SHIPPING

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