[Ala286]-Calmodulin-Dependent Protein Kinase II (281-302) ((Ala286)-CaMK-II (281-302)) CAS NO.141055-85-8

<p>[Ala²⁸⁶]-Calmodulin-Dependent Protein Kinase II (281-302) ((Ala²⁸⁶)-CaMK-II (281-302)) is a high-purity, modified synthetic peptide designed for biochemical and signaling research. The product's complete technical specifications, including its CAS number, molecular formula, and molecular weight, are provided in the accompanying data sheet. This research-grade reagent is tailored for studying CaMK-II function …

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Ala²⁸⁶]-Calmodulin-Dependent Protein Kinase II (281-302) ((Ala²⁸⁶)-CaMK-II (281-302))
CAS NO.	141055-85-8
Appearance	White to off-white lyophilized powder
Molecular Formula	C111H191N39O29S2
Molecular Weight	2600.12/mol
Amino Acid Sequence	Ac-RQEITVKKLKQLKTNLLIAKTVAEGLAQET-NH₂ (human CaMK-II residues 281–302 with Ala substitution at position corresponding to 286; actual position numbering may vary)
Purity (RP-HPLC)	≥95.0%
Solubility	Soluble in water, PBS, or dilute acetic acid solution; may require brief sonication
Endotoxin	≤1.0 EU/mg
Biological Activity	Synthetic peptide with Ala substitution at position 286; used as a substrate, inhibitor, or tool in CaMK-II activity studies, calcium/calmodulin signaling research, and neurological/cardiovascular disease models.
Storage Conditions	Store at –20°C, protected from light and moisture. For long-term storage, recommend –80°C.
Stock Location	Stock in USA
MOQ	10mg

1.MECHANISM OF ACTION

This peptide acts as a substrate or modulator for CaMK-II, a key enzyme in calcium/calmodulin signaling. Its sequence, containing a specific alanine substitution at position 286, is used to probe phosphorylation events, enzyme kinetics, and the structural determinants of CaMK-II activity in cellular regulation.

2.PRODUCT INDICATIONS

[Ala²⁸⁶]-CaMK-II (281-302) is primarily used in kinase activity assays, signal transduction research, and studies of neuronal and cardiac function. It is a critical tool for investigating the role of CaMK-II in synaptic plasticity, gene expression, and disease models associated with calcium signaling dysregulation.

3.CLINICAL EFFICACY OF PRODUCT

As a research tool, this peptide itself is not intended for clinical use. Its efficacy lies in enabling foundational and translational studies that elucidate the molecular mechanisms of CaMK-II, thereby contributing to the understanding and potential future treatment of neurological, cardiovascular, and metabolic disorders.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight

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