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Chemicals
Myristoylated Protein Kinase C (19-31)
<p>Myristoylated Protein Kinase C (19-31) is a high-purity peptide fragment with the molecular formula C₈₁H₁₄₄N₂₆O₂₆ and a molecular weight of 1754.23, featuring an N-terminal myristoyl group for membrane targeting; this product serves as a critical tool for investigating protein kinase C (PKC) signaling pathways, including membrane association, diacylglycerol (DAG)-mediated activation, and downstream regulation of …
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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About this product
Product information from the supplier.
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Myristoylated Protein Kinase C (19-31) |
| CAS NO. | \ |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₈₁H₁₄₄N₂₆O₂₆ |
| Molecular Weight | 1754.23g/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in water, phosphate-buffered saline (PBS, pH 7.2-7.4), or 0.1% trifluoroacetic acid (TFA). |
| Endotoxin | ≤1.0 EU/mg |
| Biological Activity | Regulates cellular processes such as proliferation, differentiation, and apoptosis via phosphorylation of target proteins. |
| Storage Conditions | Store lyophilized powder at -20°C in a dry, light-protected environment. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Membrane Anchoring: The covalently attached myristoyl group inserts into lipid bilayers, localizing the peptide to membrane microdomains (e.g., lipid rafts) where PKC substrates and activators (DAG, Ca²⁺) are concentrated.
Kinase Activation: Binds to DAG and calcium ions, inducing a conformational change that relieves autoinhibition and activates the kinase domain.
Signal Transduction: Phosphorylates serine/threonine residues on target proteins (e.g., MARCKS, Raf-1, transcription factors), amplifying signals that regulate cell growth, survival, and gene expression.
2.PRODUCT INDICATIONS
Cell Biology Research: Studies on PKC membrane targeting, subcellular localization, and signal transduction mechanisms.
Pharmacology: Screens for PKC modulators (activators/inhibitors) targeting diseases linked to dysregulated PKC activity (e.g., cancer, diabetes, cardiovascular disorders).
Disease Modeling: Investigates PKC’s role in pathological processes such as tumorigenesis, neurodegeneration, and immune dysfunction.
Biophysical Assays: Validates membrane-protein interactions and kinase activity in reconstituted lipid systems.
3.CLINICAL EFFICACY OF PRODUCT
Preclinical Validation: Demonstrates dose-dependent membrane binding and kinase activity in vitro, with EC₅₀ values determined in DAG/Ca²⁺-dependent activation assays.
Functional Relevance: Mimics native PKC fragment behavior in cellular models, regulating cell proliferation and apoptosis in cancer cell lines.
Translational Potential: Serves as a benchmark compound for developing PKC-targeted therapies, with applications in oncology, metabolic disorders, and inflammatory diseases.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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Global Technology Co., Ltd.
