Calmodulin-Dependent Protein Kinase II (281-309) CAS NO.116826-37-0

<p>Calmodulin-Dependent Protein Kinase II (281-309) (CAS No. 116826-37-0) is a high-purity synthetic peptide. The product specification sheet provides the detailed molecular formula, molecular weight, and other key parameters. This peptide is designed for biochemical and signaling research, particularly in studies of calcium/calmodulin-dependent pathways.<br/></p>

SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Calmodulin-Dependent Protein Kinase II (281-309)
CAS NO.	116826-37-0
Appearance	White to off-white lyophilized powder
Molecular Formula	C146H254N46O39S3
Molecular Weight	3374.11/mol
Amino Acid Sequence	R‑Q‑E‑I‑T‑V‑K‑K‑L‑K‑Q‑L‑K‑T‑N‑L‑L‑I‑A‑K‑T‑V‑K‑E‑G‑L‑A‑Q‑E‑T (single‑letter notation, corresponding to CaMKII residues 281‑309)
Purity (RP-HPLC)	≥95.0%
Solubility	Soluble in water, PBS, or dilute acetic acid solution; may require brief sonication
Endotoxin	≤1.0 EU/mg
Biological Activity	Synthetic peptide corresponding to a functional region of CaMKII; used as substrate, inhibitor, or antigen in kinase studies, signal transduction research, and antibody production.
Storage Conditions	Store at –20°C, protected from light and moisture. For long-term storage, recommend –80°C.
Stock Location	Stock in USA
MOQ	10mg

1.MECHANISM OF ACTION

This peptide represents a functional sequence of CaMKII that binds to calmodulin in a calcium-dependent manner. Upon binding, it undergoes a conformational change that activates its kinase activity, leading to the phosphorylation of downstream target proteins and the regulation of various cellular processes, including synaptic transmission, gene expression, and cytoskeletal dynamics.

2.PRODUCT INDICATIONS

Calmodulin-Dependent Protein Kinase II (281-309) is used in research to investigate calcium-mediated signal transduction, neuronal function, and cellular regulation. It serves as a valuable tool in kinase activity assays, antibody production, and studies of diseases associated with CaMKII dysregulation, such as neurological and cardiac disorders.

3.CLINICAL EFFICACY OF PRODUCT

As a research reagent, this peptide is not intended for clinical use. Its value lies in enabling fundamental and translational research that contributes to the understanding of CaMKII's role in physiology and pathology, thereby supporting the future development of diagnostic and therapeutic strategies.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight

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