gp100 (457-466)

<p>gp100 (457-466) is a high-purity, research-grade peptide designed for advanced immunotherapy and cancer research. The detailed technical specifications, including CAS number, molecular formula, molecular weight, and other critical parameters, are documented in the product's accompanying Certificate of Analysis (COA) and technical data sheet. This product is a key tool for investigating immune responses agains…

SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com

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Peptides

About this product

Product information from the supplier.

TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	gp100 (457-466)
CAS NO.
Appearance	White to off-white lyophilized powder
Molecular Formula	C47H85N13O15
Molecular Weight	1035.24g/mol
Amino Acid Sequence	H-LELDGTATL-OH (human gp100 residues 457‑466, HLA‑A*0201‑restricted epitope)
Purity (RP-HPLC)	≥95.0%
Solubility	Soluble in DMSO, PBS, or sterile water (may require sonication)
Endotoxin	≤1.0 EU/mg
Biological Activity	HLA‑A*0201‑restricted melanoma‑associated antigen peptide; used in cancer immunotherapy research, T‑cell activation studies, and vaccine development.
Storage Conditions	Store at –20°C, protected from light and moisture. For long-term storage, recommend –80°C.
Stock Location	Stock in USA
MOQ	10mg

1.MECHANISM OF ACTION

This peptide functions as a HLA-A*0201-restricted antigenic epitope derived from the gp100 melanoma-associated antigen. It is presented on the surface of antigen-presenting cells, leading to the activation and proliferation of cytotoxic T lymphocytes (CTLs) that specifically target and destroy gp100-expressing tumor cells, thereby initiating a targeted anti-tumor immune response.

2.PRODUCT INDICATIONS

gp100 (457-466) is primarily used in the research and development of cancer immunotherapies, including peptide-based vaccines and adoptive T-cell therapies, specifically for melanoma. It is also employed in immunological assays, T-cell activation studies, and preclinical evaluation of immune checkpoint combination strategies.

3.CLINICAL EFFICACY OF PRODUCT

Clinical studies involving gp100 (457-466) in combination with immune-modulating agents have demonstrated its potential to elicit antigen-specific T-cell responses and contribute to tumor regression in a subset of melanoma patients. Its efficacy underscores its role as a critical component in the development of next-generation immunotherapeutic strategies.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.