gp100 (177-186)

<p>gp100 (177-186) is a high-purity synthetic peptide representing the HLA-A*0201-restricted cytotoxic T lymphocyte (CTL) epitope derived from the human melanoma-associated antigen gp100/pMel 17. This 10-amino acid peptide (VLTPSGWTYV) is specifically designed for cancer immunotherapy research, serving as a potent immunogenic epitope that can be presented by MHC class I molecules to activate antigen-specific CD8+ T …

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	gp100 (177-186)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C45H76N12O15S2
Molecular Weight	1089.31g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in DMSO, DMF, PBS (pH 7-8), or physiological saline.
Endotoxin	< 1.0 EU/mg
Biological Activity	The HLA-A*0201-restricted CTL epitope of human melanoma-associated antigen gp100/pMel 17 can induce a specific CD8+ T cell immune response, and can be used for tumor immunology, vaccines and T cell therapy research.
Storage Conditions	Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

gp100 (177-186) functions as a tumor-associated antigen peptide that binds to HLA-A0201 molecules on antigen-presenting cells (APCs), forming peptide-MHC complexes that are recognized by T cell receptors (TCRs) on CD8+ T cells. This interaction triggers T cell activation, proliferation, and differentiation into cytotoxic T lymphocytes (CTLs). The activated CTLs then recognize and eliminate tumor cells expressing the gp100 antigen through perforin/granzyme-mediated cytotoxicity and cytokine release (such as IFN-γ). The peptide's immunogenicity is enhanced by its high affinity for HLA-A0201, making it a potent inducer of antigen-specific T cell responses in both in vitro and in vivo settings.

2.PRODUCT INDICATIONS

T Cell Activation Studies: In vitro stimulation and expansion of antigen-specific CD8+ T cells

Cancer Vaccine Development: Assessment of gp100-based vaccine candidates in preclinical models

Immune Monitoring: ELISPOT, intracellular cytokine staining, and tetramer assays for T cell detection

TCR Screening: Identification and validation of T cell receptors specific for gp100 epitope

Adoptive Cell Therapy: Generation of gp100-specific T cells for adoptive transfer studies

Cancer Immunotherapy Research: Evaluation of T cell responses and immune activation in melanoma and other malignancies

3.CLINICAL EFFICACY OF PRODUCT

Immunogenic Activity: Validated for T cell activation in HLA-A*0201-restricted systems

Sequence Accuracy: Verified 10-amino acid sequence (VLTPSGWTYV) corresponding to gp100 177-186

Research Reproducibility: Consistent performance in T cell stimulation and immune assays

Quality Documentation: Certificate of Analysis provided with purity, mass spec, and analytical data

Technical Support: Access to application guidance for cancer immunotherapy research

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.