GIP (1 – 30), porcine, amide CAS NO.134846-93-8

GIP (1-30), porcine, amide (CAS NO. 134846-93-8) is a 30-amino-acid peptide with the molecular formula C₁₆₂H₂₄₅N₄₁O₄₇S and molecular weight 3551.07 g/mol. As a C-terminally amidated analog of glucose-dependent insulinotropic polypeptide (GIP) from pigs, it is a key research tool for studying GIP-GIPR interactions, glucose metabolism, and incretin-based diabetes therapies.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	GIP (1 - 30), porcine, amide
CAS NO.	134846 - 93 - 8
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₆₂H₂₄₅N₄₁O₄₇S
Molecular Weight	3551.07g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water and can also dissolve in some polar organic solvents
Endotoxin	≤1.0 EU/mg
Biological Activity	GIP is an intestinal hormone that plays an important role in regulating blood glucose and energy metabolism. GIP (1-30), porcine, amide can bind to the GIP receptor and activate downstream signaling pathways.
Storage Conditions	Store at -20°C to maintain its stability and biological activity.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

GIP Receptor (GIPR) Binding: Binds to the GIP receptor (GIPR) on pancreatic β-cells, adipose tissue, and the central nervous system with high affinity (EC₅₀: 0.05–0.5 nM).

Glucose-Dependent Insulin Secretion: Stimulates insulin release from pancreatic β-cells via Gαs-protein-coupled signaling, increasing intracellular cAMP levels and enhancing insulin granule exocytosis—only when blood glucose is elevated.

Lipid Metabolism Regulation: Promotes triglyceride storage in adipose tissue by activating lipoprotein lipase (LPL) and inhibiting lipolysis via GIPR-mediated pathways.

C-Terminal Amidation: The amidated C-terminus (NH₂) improves peptide stability in vivo (half-life: ~5 minutes vs. 2 minutes for non-amidated forms) and strengthens receptor binding.

2.PRODUCT INDICATIONS

Diabetes Research: Studying glucose-dependent insulin secretion mechanisms and evaluating GIP analogs as adjuncts to GLP-1 receptor agonists for type 2 diabetes.

Incretin Biology: Investigating GIP-GIPR signaling in pancreatic β-cell function, adipose metabolism, and central appetite regulation.

Species Comparison: Comparing porcine GIP (vs. human/mouse GIP) to elucidate evolutionary conservation of incretin functions.

Drug Development: Screening GIPR agonists/antagonists for obesity, metabolic syndrome, or cachexia therapies.

3.CLINICAL EFFICACY OF PRODUCT

Insulin Secretion: In porcine pancreatic islet cultures, 1 nM GIP (1-30) amide increased glucose-stimulated insulin release by 3–5x vs. baseline.

Glucose Homeostasis: In diabetic rat models, co-administration with GLP-1 increased glucose clearance by 40% and reduced HbA1c by 1.2% over 4 weeks.

Adipose Metabolism: In human adipocytes, it enhanced LPL activity by 60% and reduced free fatty acid release by 35% (1 nM, 24 hours).

4.DELIVERY & SHIPPING

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