GIP, porcine

<p>GIP, Porcine (Gastric Inhibitory Polypeptide), also known as Glucose-dependent Insulinotropic Polypeptide, is a 42-amino acid incretin hormone isolated from or synthesized to match the porcine (pig) species. This peptide is secreted by K-cells in the duodenum and jejunum in response to nutrient ingestion. While named for its initial discovery as a gastric acid inhibitor, its primary and more significant role is a…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	GIP, porcine
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C225H342N60O66S
Molecular Weight	4975.66g/mol
Purity (RP-HPLC)	≥95%
Solubility	Soluble in water (≥5 mg/mL) and dilute aqueous buffers (pH 7.0–8.0).
Endotoxin	≤1.0 EU/mg
Biological Activity	Potent insulinotropic activity; stimulates insulin secretion in the presence of elevated glucose levels
Storage Conditions	Store at ≤-20°C in a desiccated environment, avoid repeated freeze-thaw cycles. Reconstituted solution.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Porcine GIP exerts its effects primarily by binding and activating the GIP Receptor (GIPR), a G-protein coupled receptor (GPCR) expressed on pancreatic beta cells, adipocytes, osteoblasts, and other tissues. Activation of GIPR is strongly glucose-dependent. In the pancreas, receptor binding stimulates Gs-protein-mediated activation of adenylate cyclase, leading to a sharp increase in intracellular cyclic AMP (cAMP).

2.PRODUCT INDICATIONS

Porcine Metabolic Research: Studying the physiology of glucose homeostasis, insulin secretion, and lipid metabolism in swine models of diabetes, obesity, or metabolic syndrome.
Comparative Incretin Biology: Investigating functional and structural similarities/differences between porcine and human incretin systems.
Pancreatic Islet & Beta-Cell Studies: Using porcine islets or beta-cell lines to examine GIP-mediated potentiation of insulin secretion and beta-cell survival.
Animal Physiology Studies: Administering to pigs to study its acute effects on gastric acid inhibition, insulin release, and postprandial metabolism.

3.CLINICAL EFFICACY OF PRODUCT

Physiological Role: As an incretin, it is a potent physiological stimulator of insulin secretion in a glucose-dependent manner, contributing significantly to postprandial glucose control.
Therapeutic Target: The human GIP system is a key component of the most effective new class of diabetes drugs: dual GLP-1/GIP receptor agonists (e.g., Tirzepatide/Mounjaro®). Tirzepatide's inclusion of GIP receptor agonism is credited with superior efficacy in lowering blood glucose and reducing body weight compared to GLP-1-only agonists.
Research Foundation: Studies using porcine GIP have been instrumental in elucidating the basic biology of the incretin system, paving the way for these clinical breakthroughs.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.