GRF (free acid) (human)

TECHNICAL SPECIFICATIONS

1.MECHANISM OF ACTION

Human GRF (free acid) functions as the native, high-affinity endogenous agonist for the Growth Hormone-Releasing Hormone Receptor (GHRHR) on pituitary somatotroph cells. Binding to this Gs-protein coupled receptor activates adenylate cyclase, leading to a significant increase in intracellular cyclic adenosine monophosphate (cAMP). 

2.PRODUCT INDICATIONS

Baseline Biological Studies: Establishing the native biological activity and potency of human GRF as a reference standard against which modified analogs (amidated, D-amino acid substituted) are compared.
Receptor-Ligand Interaction Research: Studying the precise binding kinetics, affinity, and conformational changes involved in the natural GRF-GHRHR interaction using surface plasmon resonance (SPR), isothermal titration calorimetry (ITC), or crystallography.
Enzymatic Degradation Studies: Investigating the kinetics and cleavage sites of proteolytic enzymes like DPP-IV on the native hormone structure.
Antibody & Assay Development: Serving as the native antigen for generating specific antibodies or as the standard in immunoassays (ELISA, RIA) designed to detect endogenous human GRF.
Physiological & Comparative Research: Studying the natural regulation of the GH axis in human cell-based systems or comparing the activity of human GRF to that of other species.
Peptide Chemistry & Modification: Used as the starting material for chemical conjugation, labeling, or specific C-terminal modifications.

3.CLINICAL EFFICACY OF PRODUCT

Physiological Role: It is the natural and potent stimulator of GH secretion. Its efficacy in eliciting GH release is well-established in human physiological studies.
Diagnostic Use: Synthetic GRF (often in stabilized forms) has been used in clinical diagnostic tests (GRF stimulation tests) to assess pituitary function and somatotroph reserve, helping diagnose the cause of growth hormone deficiency.
Therapeutic Development: The short half-life of the native peptide prompted the development of stabilized analogs. Tesamorelin, a DPP-IV-resistant GRF analog, is an FDA-approved drug based on this hormone's action, demonstrating the clinical efficacy achievable by modifying the native sequence.
Research Relevance: This native form remains the critical reference molecule for all biomedical research aimed at understanding GH regulation and for developing improved therapeutic analogs. Its "efficacy" in a clinical context is realized through its synthetic, stabilized derivatives.



4.DELIVERY & SHIPPING


We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods 
Main Method: International Air Freight


We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.