Growth Hormone Releasing Factor, GRF (1-44), amide, bovine

<p>Growth Hormone Releasing Factor, GRF (1-44), amide, bovine is a high-purity synthetic peptide corresponding to the 44-amino acid sequence of bovine growth hormone-releasing hormone (GHRH). This bioactive peptide functions as a potent and specific agonist for GHRH receptors, stimulating growth hormone secretion from pituitary somatotrophs. With HPLC-verified purity and comprehensive analytical documentation, it pr…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Growth Hormone Releasing Factor, GRF (1-44), amide, bovine
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C220H366N72O66S
Molecular Weight	5107.88 g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in water, acetic acid (0.1%), and DMSO; may require gentle vortexing for complete dissolution
Endotoxin	< 1.0 EU/mg
Biological Activity	Growth hormone-releasing hormone (GHRH) agonist; stimulates growth hormone secretion from anterior pituitary somatotrophs via activation of GHRH receptor.
Storage Conditions	Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Growth Hormone Releasing Factor, GRF (1-44), amide, bovine binds with high affinity to GHRH receptors on pituitary somatotroph cells, activating G-protein coupled signaling pathways. This binding stimulates adenylate cyclase activity, increasing intracellular cAMP levels and activating protein kinase A (PKA). The downstream effects include phosphorylation of transcription factors (such as CREB), enhanced growth hormone gene expression, and stimulation of growth hormone synthesis and secretion. The C-terminal amidation enhances peptide stability and receptor binding affinity, while the bovine sequence exhibits cross-reactivity with multiple species' GHRH receptors, making it valuable for comparative endocrine studies.

2.PRODUCT INDICATIONS

Endocrine Research: Investigation of growth hormone regulation, pituitary function, and growth axis signaling in bovine and cross-species models

Metabolic Studies: Research on growth hormone's role in metabolism, body composition, and energy homeostasis

Animal Model Development: Use in bovine models and cross-species studies of growth hormone deficiency and metabolic disorders

Drug Discovery: Screening for GHRH receptor agonists or antagonists for therapeutic applications

Receptor Pharmacology: Study of GHRH receptor binding, signal transduction, and species cross-reactivity

Preclinical Studies: Evaluation of growth-promoting effects and endocrine system modulation in multiple species

3.CLINICAL EFFICACY OF PRODUCT

Validated Bioactivity: Demonstrated potent stimulation of growth hormone secretion in pituitary cells and in vivo models across multiple species

High Purity: ≥95% by RP-HPLC with mass spectrometry confirmation of sequence and C-terminal amidation

Cross-Species Reactivity: Exhibits activity in bovine, rodent, and other mammalian systems, enabling comparative studies

Research Reproducibility: Consistent performance in growth hormone release assays, receptor binding studies, and animal experiments

Quality Assurance: Produced under controlled conditions with low endotoxin levels for research applications

Translational Relevance: Supports preclinical research on growth disorders, metabolic diseases, and endocrine therapeutics using multiple model systems

Documentation: Each batch includes Certificate of Analysis with purity, mass spec, and biological activity data

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.