[Trp3,Arg5]-Ghrelin (1-5) CAS NO. 848442-59-1

<p>[Trp3,Arg5]-Ghrelin (1-5) is a synthetic pentapeptide analog derived from the N-terminal bioactive core of ghrelin, featuring specific amino acid substitutions at positions 3 and 5. This analog has the sequence <strong>H-Gly-Ser-Trp-Arg-Leu-OH</strong> (with tryptophan at position 3 and arginine at position 5). Designed to mimic the minimal active region of ghrelin necessary for Growth Hormone Secretagogue Recept…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Trp3,Arg5]-Ghrelin (1-5)
CAS NO.	848442-59-1
Appearance	White to off-white lyophilized powder
Molecular Formula	C31H41N9O7
Molecular Weight	651.73g/mol
Purity (RP-HPLC)	≥98.0%
Solubility	Soluble in water (≥10 mg/mL), dilute acetic acid, and DMSO
Endotoxin	< 1.0 EU/mg
Biological Activity	A modified ghrelin fragment that acts as a selective agonist for the ghrelin receptor (GHSR-1a), with potent appetite-stimulating effects.
Storage Conditions	Store at -20°C to -80°C in a sealed container, protected from moisture and light. Stable for 1 year at -20°C, 2 years at -80°C. Avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This analog functions primarily as a Growth Hormone Secretagogue Receptor 1a (GHSR1a) agonist or partial agonist. The N-terminal 1-5 sequence of ghrelin is known to be the minimal fragment retaining binding affinity to GHSR1a, a G-protein coupled receptor. The [Trp3,Arg5] substitutions are designed to enhance receptor interaction, stability, or selectivity. Upon binding, it activates the Gq/11 signaling pathway, leading to phospholipase C (PLC) activation, inositol trisphosphate (IP3) production, diacylglycerol (DAG) release, intracellular calcium mobilization, and ultimately growth hormone (GH) release from the pituitary.

2.PRODUCT INDICATIONS

Structure-Activity Relationship (SAR) Studies: Investigating the impact of specific amino acid substitutions (Trp3, Arg5) on receptor binding affinity, selectivity, and functional activity at GHSR1a.
Minimal Active Sequence Research: Defining the shortest peptide sequence required for GHSR1a activation and studying the bioactivity of ghrelin fragments.
In VitroReceptor Pharmacology: Serving as a reference ligand or tool compound in GHSR1a binding assays (competitive displacement) and functional assays (e.g., calcium flux, inositol phosphate accumulation).
Drug Discovery: Used as a scaffold or lead compound in the design and development of novel GHSR1a agonists, antagonists, or allosteric modulators with improved pharmacokinetic properties.
Physiological Studies: Exploring the potential biological roles of truncated ghrelin peptides in growth hormone regulation, appetite, and metabolism in preclinical models.

3.CLINICAL EFFICACY OF PRODUCT

Research Utility: Its value lies in basic science and drug discovery. Studies using this analog help elucidate how specific amino acids in ghrelin contribute to receptor binding and activation, guiding the rational design of future therapeutics.
Therapeutic Target Validation: Research with such analogs validates GHSR1a as a target for conditions like growth hormone deficiency, cachexia, or obesity.
Clinical Translation Gap: This specific peptide is not a drug candidate itself. Any clinical application would stem from the development of optimized, stable, and safe GHSR1a modulators (agonists or antagonists) whose design may be informed by studies with fragments like this one.
Status: No clinical trials have been conducted with [Trp3,Arg5]-Ghrelin (1-5). Its efficacy is measured in terms of in vitroreceptor potency and in vivoactivity in animal models, not in human patients.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.