Biotin – Gastrin (1-17)

<p>Biotin-Gastrin (1-17) is a high-purity synthetic peptide consisting of the N-terminal 17 amino acids of gastrin conjugated with biotin at the N-terminus. This biotinylated derivative retains the biological activity of native gastrin while enabling efficient detection and purification through streptavidin-based systems. With HPLC-verified purity and comprehensive analytical documentation, it provides researchers w…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Biotin-Gastrin (1-17)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C107H140N22O34S2
Molecular Weight	2342.56 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, DMSO, or PBS (pH 7-8); gentle sonication may be necessary to aid dissolution.
Endotoxin	< 1.0 EU/mg
Biological Activity	Biotin-labeled gastrin 1-17 fragments; retains gastrin/CCK-B receptor binding activity, suitable for streptavidin-based detection, pull-down assays, cell imaging, etc.
Storage Conditions	Store at -20°C, protected from light and moisture. After reconstitution, aliquot and store at -20°C.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Biotin-Gastrin (1-17) functions as a selective agonist for gastrin/cholecystokinin-B (CCK-B) receptors, binding with high affinity to activate G-protein coupled signaling pathways. The biotin moiety does not interfere with receptor binding but enables efficient capture and detection through streptavidin-biotin interactions. Upon receptor binding, it stimulates intracellular calcium mobilization, activates protein kinase C, and promotes downstream effects including gastric acid secretion, mucosal cell proliferation, and regulation of gastrointestinal motility. The biotin tag facilitates applications in affinity purification, receptor localization, and high-sensitivity detection assays.

2.PRODUCT INDICATIONS

Receptor Binding Studies: Competitive binding assays, receptor affinity determination, and saturation binding experiments

Cell Imaging & Localization: Fluorescence-based detection of gastrin receptors in cells and tissues using streptavidin conjugates

Protein Interaction Research: Pull-down assays, co-immunoprecipitation, and protein complex isolation

Gastrointestinal Research: Investigation of acid secretion, mucosal growth, and gut hormone signaling

Drug Discovery: Screening for gastrin receptor modulators and therapeutic development

Diagnostic Development: Development of sensitive detection assays for gastrin-related biomarkers

3.CLINICAL EFFICACY OF PRODUCT

Validated Bioactivity: Demonstrated receptor binding affinity and functional activity comparable to native gastrin

High Purity: ≥95% by RP-HPLC with mass spectrometry confirmation of biotin conjugation and sequence

Enhanced Detection Capability: Biotin tag enables sensitive detection with streptavidin-based systems (detection limit typically<1 nm="">

Research Versatility: Suitable for ELISA, Western blot, flow cytometry, immunohistochemistry, and affinity purification applications

Quality Assurance: Produced under controlled conditions with low endotoxin levels for research use

Reproducible Performance: Consistent results in receptor binding assays, cell-based studies, and detection systems

Translational Utility: Supports preclinical research on gastrointestinal disorders, receptor pharmacology, and diagnostic assay development

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.