Gastrin I (1-14) (human) CAS NO.100940-57-6

<p>Gastrin I (1-14) (human) (CAS 100940-57-6) is a high-purity synthetic peptide fragment corresponding to the N-terminal 14 amino acids of human gastrin I. This bioactive peptide functions as a selective agonist for gastrin/cholecystokinin-B (CCK-B) receptors, making it an essential research tool for studying gastrointestinal physiology, acid secretion regulation, and receptor pharmacology. Supplied as a white to o…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Gastrin I (1-14) (human)
CAS NO.	100940-57-6
Appearance	White to off-white lyophilized powder
Molecular Formula	C79H100N16O27
Molecular Weight	1705.76 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, acetic acid (0.1%), DMSO; may require gentle vortexing or sonication
Endotoxin
Biological Activity	Gastrin/cholecystokinin-B receptor agonist; stimulates gastric acid secretion and mucosal growth.
Storage Conditions	Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Gastrin I (1-14) (human) binds with high affinity to gastrin/CCK-B receptors on gastric parietal cells and other target tissues. This binding activates G-protein coupled signaling pathways, leading to increased intracellular calcium mobilization and activation of protein kinase C. The downstream effects include stimulation of gastric acid secretion, promotion of gastric mucosal cell proliferation, and modulation of gastrointestinal motility. Unlike full-length gastrin, this fragment retains receptor-binding activity while offering specificity for mechanistic studies of receptor-ligand interactions.

2.PRODUCT INDICATIONS

Gastrointestinal Research: Investigation of gastric acid secretion, mucosal growth, and gut hormone regulation

Receptor Pharmacology: Study of gastrin/CCK-B receptor signaling, binding affinity, and receptor subtype specificity

Drug Discovery: Screening and development of gastrin receptor agonists or antagonists for therapeutic applications

Metabolic Studies: Exploration of gastrin's role in appetite regulation, nutrient absorption, and metabolic disorders

Cell Signaling Research: Analysis of intracellular signaling pathways activated by gastrin receptor stimulation

3.CLINICAL EFFICACY OF PRODUCT

Validated Bioactivity: Demonstrated receptor binding and functional activity in gastric acid secretion assays and cell-based models

High Purity: ≥95% by RP-HPLC with mass spectrometry confirmation of sequence and molecular weight

Reproducible Performance: Consistent results in receptor binding studies, acid secretion experiments, and signaling pathway analysis

Research Versatility: Suitable for in vitro cell culture studies, ex vivo tissue preparations, and in vivo animal models

Quality Assurance: Produced under controlled conditions with low endotoxin levels for research applications

Translational Relevance: Supports preclinical research on peptic ulcer disease, Zollinger-Ellison syndrome, and gastrointestinal cancers

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

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