Gastrin I (rat) CAS NO.81123-06-0

Gastrin I (Rat) (CAS 81123-06-0) is the predominant 17-amino acid, non-sulfated isoform of the gastrin hormone specifically isolated from or synthesized to match rat species. This peptide contains the C-terminal tetrapeptide amide sequence (Trp-Met-Asp-Phe-NH₂) which is essential for biological activity and receptor binding. It plays a critical role in stimulating gastric acid secretion and mucosal growth in rodent …

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Gastrin I (rat) (Rat Gastrin-17)
CAS NO.	81123-06-0
Appearance	White to off-white lyophilized solid powder
Molecular Formula	C94H128N22O31S2
Molecular Weight	2126.3g/mol
Purity (RP-HPLC)	≥98.0%
Solubility	Soluble in DMSO (≥27.5 mg/mL), water, and dilute aqueous acids.
Endotoxin	≤5.0 EU/mg
Biological Activity	Potent stimulator of gastric acid secretion; binds to cholecystokinin B (CCK2) receptors to induce histamine release and gastric motility.
Storage Conditions	-20°C to -80°C (sealed, away from moisture and light). Stable for 1 year at -20°C, 2 years at -80°C. Avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Gastrin I (Rat) exerts its biological effects by binding and activating the cholecystokinin-B/gastrin receptor (CCK₂R or CCKBR), a G protein-coupled receptor highly expressed on gastric parietal cells and enterochromaffin-like (ECL) cells in the stomach. The binding event triggers Gq/11 protein activation, leading to phospholipase C (PLC) stimulation. This results in the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP₂) into inositol trisphosphate (IP₃) and diacylglycerol (DAG).

2.PRODUCT INDICATIONS

Rodent Gastrointestinal Physiology: Studying the regulation of gastric acid secretion, mucosal growth, and gastrointestinal motility in rats.

Species-Specific Hormone Research: Investigating the structure-function relationship and signaling of gastrin in rat tissues and cell lines.

In VivoModeling: Administering to rats to create models of hypergastrinemia, investigate acid-related disorders, or study gastrin's trophic effects.

In VitroReceptor Studies: Serving as the native ligand for CCK₂R in binding assays, autoradiography, and functional studies using rat-derived tissues or cells.

Drug Discovery & Pharmacology: Testing the efficacy of gastrin receptor antagonists or acid-suppressing drugs in rat-based assay systems.

Comparative Endocrinology: Comparing biological activity and receptor affinity across different species (rat vs. human vs. mouse gastrin).

3.CLINICAL EFFICACY OF PRODUCT

Research Validation: Its efficacy is well-established in rat physiology. Studies show it potently stimulates gastric acid secretion and induces mucosal hyperplasia in rats, making it a standard tool for creating experimental models.
Translation to Human Health: Research using this peptide in rat models has been fundamental in understanding the pathophysiology of conditions like Zollinger-Ellison syndrome, peptic ulcers, and gastric cancer, informing human clinical strategies.
Diagnostic/Therapeutic Gap: The peptide itself is not used as a drug or diagnostic in humans. Its value lies entirely in generating preclinical data.
Regulatory Status: It is not an approved therapeutic agent. Any future human drug development targeting the gastrin pathway would involve human-specific analogs or receptor modulators, not the rat peptide.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight

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