Biotin-[Glu1]-Gastrin I (human) (phosphorylated)

Biotin-[Glu1]-Gastrin I (human) (phosphorylated) is a modified neuropeptide with the molecular formula C₁₀₇H₁₄₁N₂₂O₃₇PS₂ and molecular weight 2422.53 g/mol. As a phosphorylated, biotin-labeled analog of human Gastrin I, it combines enhanced stability with sensitive detection capabilities, making it indispensable for studying gastrin metabolism, CCK₂ receptor signaling, and developing phospho-specific diagnostic tool…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Biotin-[Glu1]-Gastrin I (human) (phosphorylated)
CAS NO.	\
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₀₇H₁₄₁N₂₂O₃₇PS₂
Molecular Weight	2422.53 g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Freely soluble in deionized water (pH 4.0–7.0) or 0.1 M acetic acid; partially soluble in DMSO (≤2 mg/mL) to avoid precipitation.
Endotoxin	< 1.0 EU/mg
Biological Activity	Phosphorylated, biotin-labeled analog of human Gastrin I, retaining CCK₂ receptor binding affinity (human CCK₂ receptor Ki: 0.1–1 nM). Phosphorylation at specific residues (e.g., Ser⁴) modulates stability and receptor interaction. Biotin enables detection via streptavidin conjugates .
Storage Conditions	Lyophilized powder: Store at -20°C in a tightly sealed, light-protected container; avoid moisture and repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

CCK₂ Receptor Activation: Retains high affinity for the cholecystokinin-2 (CCK₂) receptor (human, Ki: 0.1–1 nM), binding to the same site as native gastrin to stimulate gastric acid secretion and mucosal growth via Gq/11-coupled signaling.

Phosphorylation-Mediated Stability: Site-specific phosphorylation (e.g., at serine residues) enhances resistance to proteolytic degradation, prolonging half-life in biological samples.

Biotin-Driven Detection: The N-terminal biotin label binds streptavidin-conjugated probes (e.g., HRP, fluorophores) with ultra-high affinity (Kd ~10⁻¹⁵ M), enabling sensitive detection in ELISA, Western blot, and immunohistochemistry.

2.PRODUCT INDICATIONS

Gastrin Metabolism Research: Studying phosphorylation-dependent regulation of gastrin stability, processing, and receptor interaction in human gastric tissues.

CCK₂ Receptor Pharmacology: Evaluating receptor agonists/antagonists using biotin-labeled gastrin to track binding kinetics and downstream signaling.

Diagnostic Tool Development: Designing phospho-gastrin-specific assays for clinical samples (e.g., serum, gastric juice) to detect hypergastrinemia or gastrinoma.

3.CLINICAL EFFICACY OF PRODUCT

Preclinical Validation:

Binds human CCK₂ receptors with 80–90% of native gastrin’s affinity (radioligand binding assays).

Resists degradation in human serum for 24+ hours (vs. 2–4 hours for unmodified gastrin).

Enables detection of phospho-gastrin in gastric cancer cell lysates at picogram levels (ELISA, LOD: 10 pg/mL).

Therapeutic Relevance: Supports development of phospho-gastrin biomarkers for early diagnosis of Zollinger-Ellison syndrome and monitoring anti-ulcer therapy efficacy.

4.DELIVERY & SHIPPING

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Shipping Methods
Main Method: International Air Freight

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