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Chemicals
Big Gastrin - 1, human CAS NO.60675-77-6
<p>Big Gastrin-1, human (CAS NO. 60675-77-6) is a high-molecular-weight neuropeptide with the molecular formula <strong>C₁₇₆H₂₅₁N₄₃O₅₃S</strong> and molecular weight <strong>3849.3 g/mol</strong>. As a key regulator of gastric function in humans, it is widely used to study gastric acid secretion, gastrin receptor pharmacology, and preclinical drug development for acid-related disorders.</p>
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Big Gastrin-1, human |
| CAS NO. | 60675-77-6 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₁₇₆H₂₅₁N₄₃O₅₃S |
| Molecular Weight | 3849.3 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Freely soluble in deionized water (pH 4.0–7.0) or 0.1 M acetic acid; partially soluble in DMSO (≤2 mg/mL) to avoid precipitation. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Potent agonist of the cholecystokinin-2 (CCK₂) receptor (human, Ki: 0.05–0.5 nM), stimulating gastric acid secretion, gastrin release, and proliferation of gastric mucosal cells. Validated for use in human-relevant pharmacological and physiological studies. |
| Storage Conditions | Lyophilized powder: Store at -20°C in a tightly sealed, light-protected container; avoid moisture and repeated freeze-thaw cycles. After reconstitution, aliquot into single-use vials and store at -80°C (stable for 6 months) or 2–8°C (stable for 1 week). |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
CCK₂ Receptor Activation: Binds to the cholecystokinin-2 (CCK₂) receptor (human-specific, Ki: 0.05–0.5 nM), triggering Gq/11 protein-coupled signaling cascades.
Gastric Acid Secretion: Stimulates enterochromaffin-like (ECL) cells in the stomach to release histamine, which induces gastrin secretion from G cells, ultimately increasing gastric acid production.
Mucosal Growth: Promotes proliferation of gastric mucosal cells via CCK₂ receptor-mediated MAPK/ERK pathway activation, supporting tissue repair and regeneration.
2.PRODUCT INDICATIONS
Gastrointestinal Research: Studying gastric acid regulation, peptic ulcer disease, and gastroesophageal reflux disorder (GERD) in human-relevant models.
Pharmacology Studies: Evaluating CCK₂ receptor antagonists (e.g., proton pump inhibitors, H₂ blockers) and agonists for acid suppression or mucosal protection.
Preclinical Drug Development: Testing the efficacy and safety of anti-ulcer drugs, gastric stimulants, or CCK₂-targeted therapies in human-derived cell lines or organoids.
3.CLINICAL EFFICACY OF PRODUCT
Increases gastric acid output by 60–80% in human gastric gland cultures (ED₅₀: 0.2 nM).
Therapeutic Relevance: CCK₂ receptor antagonists derived from Big Gastrin-1, human are in clinical trials for acid-related disorders, with this peptide serving as a key reference standard.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
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Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Main Method: International Air Freight
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