Gastrin Releasing Peptide, human CAS NO.93755-85-2

Gastrin Releasing Peptide, human (CAS NO. 93755-85-2) is a 27-amino-acid neuropeptide with the molecular formula C₁₃₀H₂₀₄N₃₈O₃₁S₂ and molecular weight 2859.4 g/mol. As a key regulator of gastrointestinal and neuroendocrine functions, it is widely studied for its roles in gastrin release, gastric acid secretion, and neuromodulation, making it indispensable for gastroenterology, neuroscience, and oncology research.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Gastrin Releasing Peptide, human
CAS NO.	93755-85-2
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₃₀H₂₀₄N₃₈O₃₁S₂
Molecular Weight	2859.4 g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in water (pH 4.0–7.0) or 0.1 M acetic acid; slightly soluble in DMSO (≤5 mg/mL)
Endotoxin	< 1.0 EU/mg
Biological Activity	Binds to gastrin-releasing peptide receptor (GRPR, BB₂) with high affinity (Ki: 0.1–1 nM), stimulating gastrin release from G cells, increasing gastric acid secretion, and modulating smooth muscle contraction. Also involved in neurotransmission, immune response, and cancer progression (e.g., prostate, breast).
Storage Conditions	Lyophilized powder: Store at -20°C in a desiccated, light-protected container; avoid repeated freeze-thaw cycles. After reconstitution, aliquot and store at -80°C (stable for 6 months) or 2–8°C (stable for 1 week).
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

GRPR Activation: Binds to the gastrin-releasing peptide receptor (GRPR/BB₂) with high affinity (Ki: 0.1–1 nM), triggering Gq/11 protein-coupled signaling cascades.

Gastrin Secretion: Stimulates enterochromaffin-like (ECL) cells to release histamine, which in turn induces gastrin secretion from G cells in the stomach antrum, driving gastric acid production.

Smooth Muscle Contraction: Modulates gastrointestinal motility by activating GRPR on smooth muscle cells, enhancing peristalsis and sphincter relaxation.

Neurotransmission: Functions as a neurotransmitter/neuromodulator in the central and peripheral nervous systems, regulating pain perception, stress responses, and memory.

2.PRODUCT INDICATIONS

Gastroenterology Research: Studying gastric acid secretion mechanisms, peptic ulcer disease, and gastroesophageal reflux disorder (GERD).

Neuroscience Studies: Investigating neuromodulatory roles in anxiety, depression, epilepsy, and neurodegenerative diseases (e.g., Alzheimer’s).

Oncology Research: Targeting GRPR-positive tumors (e.g., prostate, breast, small cell lung cancer) for diagnostic imaging or radiopharmaceutical development.

3.CLINICAL EFFICACY OF PRODUCT

Increases gastrin release by 3–5x in isolated rat G cells (ED₅₀: 0.5 nM).
Enhances gastric acid output by 40–60% in pylorus-ligated rat models.
Reduces pain responses in neuropathic pain models (spinal nerve ligation) by 30–50% (GRPR-mediated antinociception).

Therapeutic Potential: GRPR antagonists derived from this peptide show promise in treating GRPR-overexpressing cancers (e.g., prostate cancer) in early-phase clinical trials.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.