Galanin-Lys(Biotin), human

Galanin-Lys(Biotin), human is a specifically engineered, biotinylated analog of the endogenous human galanin neuropeptide. This synthetic 30-amino acid peptide features a lysine residue conjugated with biotin, typically at the C-terminus or a designated position, allowing for high-affinity capture and detection via streptavidin/avidin systems. It retains full biological activity of native human galanin while enablin…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Galanin-Lys(Biotin), human
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C155H237N46O46S
Molecular Weight	3511.95 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water (≥5 mg/mL), dilute acetic acid, and DMSO
Endotoxin	< 1.0 EU/mg
Biological Activity	Retains agonist activity at GALR1, GALR2, and GALR3; biotin label enables detection via streptavidin conjugates.
Storage Conditions	Store at -20°C to -80°C; avoid repeated freeze-thaw cycles. Reconstituted solution can be stored at 4°C for up to 1 week or at -20°C for up to 3 months.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This biotinylated analog functions identically to native human galanin by binding and activating specific G protein-coupled galanin receptors (GalR1, GalR2, GalR3). Upon receptor engagement, it initiates downstream signaling cascades: GalR1/GalR3 coupling inhibits adenylate cyclase (reducing cAMP), while GalR2 coupling stimulates phospholipase C (increasing IP₃ and intracellular calcium). The covalently attached biotin moiety does not interfere with receptor affinity or signaling activity but provides a stable handle for streptavidin conjugation.

2.PRODUCT INDICATIONS

Receptor Localization Studies: Histochemistry, immunofluorescence, or electron microscopy to visualize galanin receptor distribution in cells or tissues.
Affinity Capture Assays: Pull-down experiments to isolate galanin-receptor complexes or interacting proteins from lysates.
Biosensor & Diagnostic Development: Immobilization on streptavidin-coated surfaces for SPR, ELISA, or other binding assays.
Signal Transduction Tracing: Tracking internalized peptide-receptor complexes to study endocytosis and intracellular trafficking.
High-Throughput Screening: Use as a tagged ligand in drug discovery platforms targeting galanin receptors.
Advanced Binding Kinetics: Quantifying receptor-ligand interactions in real-time using biotin-streptavidin detection systems.

3.CLINICAL EFFICACY OF PRODUCT

Preclinical utility is well-established in mechanistic studies, where it has been instrumental in mapping galanin receptor expression in brain regions involved in pain, cognition, and feeding.
No clinical trials have been conducted using biotinylated galanin as a therapeutic agent. Its role is entirely confined to basic and translational research.
Indirect clinical relevance stems from its use in developing diagnostic assays or in validating mechanisms that inform drug discovery. For example, it may be used in pharmacodynamic assays to measure target engagement of novel galanin receptor modulators in preclinical development.
Any future therapeutic potential would reside in native galanin or its non-tagged analogs, not in this detection-focused derivative.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.