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Chemicals
Biotin-Galanin, human
<p>Galanin, rat (CAS NO. 114547-31-8) is a 29-amino-acid neuropeptide with the molecular formula <strong>C₁₄₁H₂₁₁N₄₃O₄₁</strong> and molecular weight <strong>3164.48 g/mol</strong>. As a key regulator of neurotransmission and homeostasis, it is widely studied for its roles in pain modulation, feeding behavior, and stress responses, making it indispensable for neuroscience research and drug development.</p>
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Biotin - Galanin, human |
| CAS NO. | \ |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C149H224N44O45S |
| Molecular Weight | 3383.78g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | The biological activity of Biotin - Galanin, human, its potency in binding to receptors or eliciting specific cellular responses. |
| Storage Conditions | Store at -20°C in a light-protected environment; avoid repeated freeze-thaw cycles. After reconstitution, aliquot and store at -80°C, where it remains stable for 6 months. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Galanin Receptor Activation: Binds to three G protein-coupled receptors (GALR1, GALR2, GALR3) with high affinity (Ki: 0.1–5 nM), inhibiting adenylate cyclase and modulating intracellular calcium levels.
Neurotransmitter Modulation: Inhibits acetylcholine release in the hippocampus, dopamine release in the striatum, and noradrenaline release in the hypothalamus, altering synaptic plasticity.
Hypothalamic Regulation: Acts on the arcuate nucleus to suppress appetite and regulate energy balance via NPY/AgRP and POMC/CART pathways.
2.PRODUCT INDICATIONS
Neuroscience Research: Studying depression, anxiety, epilepsy, and neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s).
Pain Management Studies: Investigating its antinociceptive effects in acute and chronic pain models (e.g., neuropathic, inflammatory pain).
Metabolic Disorder Research: Exploring its role in obesity, anorexia, and diabetes via hypothalamic feeding regulation.
3.CLINICAL EFFICACY OF PRODUCT
Reduces pain responses by 40–60% in rodent models of neuropathic pain (spinal nerve ligation).
Decreases food intake by 30–50% in diet-induced obese rats, improving insulin sensitivity.
Attenuates anxiety-like behaviors in mice (elevated plus maze test) by 50–70%.
Therapeutic Potential: Agonists targeting GALR1/GALR2 show promise for treating chronic pain, obesity, and mood disorders in early-phase clinical trials.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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