Galanin, rat CAS NO.114547-31-8

Galanin, rat (CAS NO. 114547-31-8) is a 29-amino-acid neuropeptide with the molecular formula C₁₄₁H₂₁₁N₄₃O₄₁ and molecular weight 3164.48 g/mol. As a key regulator of neurotransmission and homeostasis, it is widely studied for its roles in pain modulation, feeding behavior, and stress responses, making it indispensable for neuroscience research and drug development.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Galanin, rat
CAS NO.	114547-31-8
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₄₁H₂₁₁N₄₃O₄₁
Molecular Weight	3164.48 g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in water (pH 4.0–7.0) or 0.1 M acetic acid; slightly soluble in DMSO (≤5 mg/mL)
Endotoxin	< 1.0 EU/mg
Biological Activity	Binds to galanin receptors (GALR1, GALR2, GALR3) with high affinity; modulates neurotransmission, pain perception, feeding behavior, and stress responses. Used to study neuroendocrine regulation and develop analgesics/anti-obesity drugs.
Storage Conditions	Store at -20°C in a desiccated, light-protected container; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Galanin Receptor Activation: Binds to three G protein-coupled receptors (GALR1, GALR2, GALR3) with high affinity (Ki: 0.1–5 nM), inhibiting adenylate cyclase and modulating intracellular calcium levels.

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Neurotransmitter Modulation: Inhibits acetylcholine release in the hippocampus, dopamine release in the striatum, and noradrenaline release in the hypothalamus, altering synaptic plasticity.

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Hypothalamic Regulation: Acts on the arcuate nucleus to suppress appetite and regulate energy balance via NPY/AgRP and POMC/CART pathways.

2.PRODUCT INDICATIONS

Neuroscience Research: Studying depression, anxiety, epilepsy, and neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s).

Pain Management Studies: Investigating its antinociceptive effects in acute and chronic pain models (e.g., neuropathic, inflammatory pain).

Metabolic Disorder Research: Exploring its role in obesity, anorexia, and diabetes via hypothalamic feeding regulation.

3.CLINICAL EFFICACY OF PRODUCT

Reduces pain responses by 40–60% in rodent models of neuropathic pain (spinal nerve ligation).

Decreases food intake by 30–50% in diet-induced obese rats, improving insulin sensitivity.

Attenuates anxiety-like behaviors in mice (elevated plus maze test) by 50–70%.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight

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