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Chemicals
Fibronectin-Binding Protein
Fibronectin-Binding Protein is a high-molecular-weight protein with the molecular formula C₁₉₀H₂₈₃N₄₉O₆₆ and molecular weight 4309.66 g/mol. As a key mediator of host-pathogen interactions, it is widely studied for its role in bacterial adhesion and fibronectin-mediated signaling, making it indispensable for infectious disease research and anti-adhesion therapy development.
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Fibronectin-Binding Protein |
| CAS NO. | \ |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₁₉₀H₂₈₃N₄₉O₆₆ |
| Molecular Weight | 4309.66 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in neutral aqueous buffers (e.g., PBS, Tris-HCl pH 7.4); partially soluble in urea or guanidine hydrochloride (for denatured studies) |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Mediates adhesion to host fibronectin matrices, facilitating pathogen colonization (e.g., bacterial biofilm formation, tissue invasion). Used to study host-pathogen interactions and fibronectin-mediated signaling. |
| Storage Conditions | Store at -80°C (long-term) or -20°C (short-term) in a desiccated, light-protected container; avoid repeated freeze-thaw cycles |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Fibronectin-Binding Protein exerts its function through:
High-Affinity Fibronectin Binding: Contains specialized domains (e.g., FnBPA/FnBPB repeats) that recognize and bind to fibronectin’s RGD (Arg-Gly-Asp) and synergy sites, enabling strong adhesion to host extracellular matrices.
Pathogen Colonization: Facilitates bacterial attachment to host tissues (e.g., skin, mucosa), promoting colonization, biofilm formation, and resistance to mechanical clearance.
Signaling Modulation: Activates host cell pathways (e.g., integrin-FAK signaling) to trigger pro-inflammatory responses or modulate cell behavior, aiding pathogen survival.
2.PRODUCT INDICATIONS
This protein is critical for:
Infectious Disease Research: Studying bacterial pathogenesis (e.g., Staphylococcus aureus, Streptococcus pyogenes) and host-pathogen interaction mechanisms.
Anti-Adhesion Therapy Development: Screening compounds that block fibronectin binding to prevent bacterial colonization (e.g., anti-virulence drug discovery).
Biomaterial Compatibility Studies: Evaluating how implant surfaces interact with fibronectin and bacterial adhesins to design infection-resistant medical devices.
3.CLINICAL EFFICACY OF PRODUCT
In Vitro Studies: Demonstrates strong fibronectin binding (Kd ~10⁻⁹ M) and promotes bacterial adhesion to fibronectin-coated surfaces (2–5x increase vs. controls).
Animal Models: In murine wound infection models, Fibronectin-Binding Protein enhances S. aureuscolonization by 60–70%, validating its role in pathogenesis.
Therapeutic Potential: Blocking its fibronectin-binding domain reduces bacterial adhesion by 80% in vitro, supporting its use as a target for anti-adhesion therapies.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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Global Technology Co., Ltd.
