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Chemicals
Fibrinopeptide A, human CAS NO.25422-31-5
Fibrinopeptide A, human (CAS NO. 25422-31-5) is a 16-amino-acid peptide derived from the α-chain of human fibrinogen, with the molecular formula C₆₃H₉₇N₁₉O₂₆ and molecular weight 1536.59 g/mol. As a key biomarker and functional molecule in blood coagulation, it plays a critical role in fibrin polymerization and thrombus formation, making it indispensable for hemostasis research and diagnostic applications.
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Fibrinopeptide A, human |
| CAS NO. | 25422-31-5 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₆₃H₉₇N₁₉O₂₆ |
| Molecular Weight | 1536.59 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water (pH 4.0–7.0) or 0.1 M acetic acid; slightly soluble in DMSO (≤5 mg/mL) |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Released from fibrinogen during thrombin-mediated cleavage; regulates fibrin polymerization and blood clotting kinetics. Used to study coagulation disorders, thrombolytic therapy, and fibrin structure-function relationships. |
| Storage Conditions | Store at -20°C in a desiccated, light-protected container; avoid repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Fibrinopeptide A is released from fibrinogen during thrombin-catalyzed cleavage (at Arg¹⁶-Gly¹⁷ bond). Its primary actions include:
Initiating Fibrin Polymerization: Removal of Fibrinopeptide A exposes polymerization sites (e.g., Gln¹⁶ and Gly¹⁷) on fibrinogen, enabling lateral aggregation of fibrin monomers into protofibrils.
Regulating Clot Structure: Modulates the density and stability of fibrin clots by influencing protofibril branching and cross-linking.
Biomarker Function: Elevated plasma levels correlate with thrombotic activity, serving as a diagnostic marker for deep vein thrombosis (DVT), pulmonary embolism (PE), and disseminated intravascular coagulation (DIC).
2.PRODUCT INDICATIONS
This peptide is widely used in:
Coagulation Research: Studying thrombin-fibrinogen interactions, fibrin assembly dynamics, and clot structure-function relationships.
Diagnostic Development: Developing ELISA kits or immunoassays for detecting hypercoagulable states (e.g., DVT, PE, sepsis-induced DIC).
Drug Screening: Evaluating anticoagulant/antithrombotic agents (e.g., direct thrombin inhibitors, fibrinogen modulators) in preclinical models.
3.CLINICAL EFFICACY OF PRODUCT
Biomarker Utility: Plasma Fibrinopeptide A levels rise 10–100-fold during active thrombosis, enabling early detection of thrombotic events (validated in clinical studies).
Research Applications: In vitro studies confirm its role in accelerating fibrin clot formation (2–3x faster polymerization vs. uncleaved fibrinogen).
Diagnostic Accuracy: ELISA-based assays using this peptide achieve >90% sensitivity/specificity for DVT diagnosis in multicenter trials.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Main Method: International Air Freight
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