Fibrinogen γ – Chain (117 – 133) CAS NO.160927-63-9

Fibrinogen γ-Chain (117-133) is a highly pure, synthetic peptide segment derived from the γ-chain of human fibrinogen. This research-grade peptide is designed to study fibrinogen-mediated biological processes, particularly in coagulation, thrombosis, and cellular adhesion. It is supplied as a white to off-white lyophilized powder with HPLC-verified purity, ensuring consistent performance for in vitro and in vivo stu…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Fibrinogen γ-Chain (117-133)
CAS NO.	160927-63-9
Appearance	White to off-white lyophilized powder
Molecular Formula	C84H147N25O27
Molecular Weight	1939.26g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, PBS (pH 7.0-7.5), dilute acetic acid; may require gentle sonication or mild acid for complete dissolution
Endotoxin	< 1.0 EU/mg
Biological Activity	Fibrinogen is a functional fragment of the γ chain; it participates in coagulation cascade reactions, platelet aggregation, and inflammation regulation; it is often used to study its interaction with receptors such as integrins and selectins, as well as its role in thrombosis, wound repair, and tumor metastasis.
Storage Conditions	Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C or -80°C; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Fibrinogen γ-Chain (117-133) binds to integrin receptors, such as αIIbβ3 (GPIIb/IIIa) on platelets, promoting platelet aggregation and fibrin clot stabilization. It also interacts with other adhesion molecules, modulating cell-matrix interactions, inflammatory signaling, and thrombus formation. This peptide mimics a functional domain critical for fibrin polymerization and cross-linking, enabling researchers to dissect fibrinogen’s role in hemostasis, thrombosis, and wound healing.

2.PRODUCT INDICATIONS

Coagulation & Thrombosis Research: Study of fibrinogen function, platelet activation, and clot formation dynamics.

Vascular & Inflammatory Disease Models: Investigation of fibrinogen’s role in atherosclerosis, deep vein thrombosis, and sepsis.

Cell Adhesion & Signaling Studies: Research on integrin-mediated pathways and extracellular matrix interactions.

Drug Discovery & Development: Screening for antithrombotic or anti-inflammatory compounds targeting fibrinogen pathways.

Biomarker & Diagnostic Tool Development: Exploration of fibrinogen peptides as indicators of thrombotic or inflammatory states.

3.CLINICAL EFFICACY OF PRODUCT

Research Reliability: Consistently active in platelet aggregation assays, clot retraction studies, and receptor binding experiments.

High Purity: ≥95% purity by RP-HPLC with mass spectrometry confirmation for sequence accuracy.

Functional Validation: Demonstrates bioactivity in preclinical models of thrombosis and inflammation.

Versatile Application: Suitable for ELISA, flow cytometry, cell culture, and animal studies.

Translational Relevance: Supports the identification of novel therapeutic targets for cardiovascular and inflammatory diseases.

Quality Assurance: Each batch includes a certificate of analysis (COA) with purity, endotoxin, and stability data.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.