Dynorphin A (1-13) Acetate CAS NO.CAS 72957-38-1

Dynorphin A (1-13) Acetate (CAS 72957-38-1) is a synthetic peptide fragment derived from the endogenous opioid peptide Dynorphin A. This 13-amino acid sequence retains the core biological activity of the full-length peptide, serving as a potent and selective kappa-opioid receptor (KOR) agonist. Supplied as a high-purity white to off-white lyophilized powder, it is an essential research tool for neuroscience, pain re…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Dynorphin A (1-13) Acetate
CAS NO.	72957-38-1
Appearance	White to off-white lyophilized powder
Molecular Formula	C75H126N24O15
Molecular Weight	1603.98 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, dilute acetic acid, and PBS buffer; may require gentle vortexing
Endotoxin	< 1.0 EU/mg
Biological Activity	Endogenous opioid peptide; selective κ-opioid receptor agonist with analgesic and neuroregulatory effects.
Storage Conditions	Store at -20°C, protected from light and moisture. After reconstitution, aliquot and store at -20°C.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Dynorphin A (1-13) Acetate functions as a selective agonist for kappa-opioid receptors (KOR) in the central and peripheral nervous systems. Upon binding, it activates Gi/o protein-coupled signaling pathways, leading to inhibition of adenylate cyclase, reduced cAMP production, and modulation of ion channel activity. This action results in hyperpolarization of neurons, decreased neurotransmitter release (particularly dopamine in the mesolimbic pathway), and modulation of pain perception, stress responses, and emotional processing.

2.PRODUCT INDICATIONS

Neuroscience Research: Investigation of kappa-opioid receptor function, signaling pathways, and neural circuitry

Pain Mechanism Studies: Research on endogenous pain modulation and analgesic systems

Psychopharmacology: Studies of stress responses, addiction mechanisms, and mood regulation

Neuropsychiatric Research: Investigation of depression, anxiety, and reward processing disorders

Drug Discovery: Screening and development of novel kappa-opioid receptor-targeted therapeutics

3.CLINICAL EFFICACY OF PRODUCT

Receptor Specificity: High selectivity for kappa-opioid receptors with minimal cross-reactivity to mu- and delta-opioid receptors

Biological Activity: Verified analgesic and anti-stress effects in validated animal models

Research Reliability: Consistent performance in receptor binding assays and functional studies

Scientific Validation: Supported by extensive literature on dynorphin physiology and opioid pharmacology

Quality Assurance: ≥95% HPLC purity with comprehensive analytical characterization

Technical Support: Available data on receptor binding constants and functional activity profiles

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.